---
title: "ESMFold2 (Biohub) - Air Market"
description: "You have a sequence and need to know what shape the molecule takes, or you designed a binder and want to check it before running an experiment. This predicts all-atom structures for proteins together…"
canonical: "https://airmarket.ai/app/esmfold2"
---

[Air Market](/) / [Research](/category/research) / ESMFold2 (Biohub)

Skill by [UnicomAI](/@unicomai)

# ESMFold2 (Biohub)

Predict how a protein complex folds from sequence alone

## What this does

You have a sequence and need to know what shape the molecule takes, or you designed a binder and want to check it before running an experiment. This predicts all-atom structures for proteins together with DNA, RNA, ligands, and modified residues, from a single sequence or from aligned ones. It also scores mutations and produces embeddings from the companion language models.

### Top 3 things it does for you

- Predict a complex structure from a single sequence
- Validate a designed binder
- Run a fold with MSA input

## Information

**ESMFold2 (Biohub) at a glance**

|  |  |
| --- | --- |
| Kind | Skill |
| Publisher | [UnicomAI](/@unicomai) |
| Category | [Research](/category/research) |
| Works with | Agent Skills - an open standard supported by 40+ agents |
| Size | 14 KB |
| Licence | Apache-2.0 |
| Repository | [UnicomAI/wanwu](https://github.com/UnicomAI/wanwu/tree/05561a42bb76e01caacedd5febd534d8508869eb/configs/microservice/bff-service/configs/agent-skills/claude-science/esmfold2) |
| GitHub stars | 2,449 (as of Nov 2026) |

## Security report

**Verified.** AIR scanned this exact version of ESMFold2 (Biohub) and flagged nothing. AIR's verdict: **safe**.

**What ESMFold2 (Biohub)'s check was run against**

|  |  |
| --- | --- |
| Commit | 05561a42bb76e01caacedd5febd534d8508869eb |
| Content hash | 921d525d32dc60eb1b4334f0b4ea600611441cf66342b26c9ea7a9687e830ae8 |
| Files read | [Browse the files at this exact commit](https://github.com/UnicomAI/wanwu/blob/05561a42bb76e01caacedd5febd534d8508869eb/configs/microservice/bff-service/configs/agent-skills/claude-science/esmfold2/SKILL.md) |

A scan is named by the exact content it read, not by a version number. A different version is a different artifact, and nothing here applies to a version AIR has not scanned.

[Read the full security report for ESMFold2 (Biohub)](/security/esmfold2)

## About ESMFold2 (Biohub)

All-atom co-folding with ESMFold2 and ESMFold2-Fast, covering proteins along with DNA, RNA, ligands specified as CCD or SMILES, and modified residues. It runs in single-sequence mode as well as with MSA input, so you can fold with or without an alignment. Reported FoldBench results include antibody-antigen and protein-protein interface accuracy.

The same release brings the ESMC protein language models, in several sizes. Through them the skill covers masked language model logits, hidden states, mutation scoring, contact prediction, and a sparse autoencoder head for interpretability.

It also covers the practical side of running these models: choosing a kernel backend and sampling-step settings that stay faithful to the paper's throughput. Weights are MIT-licensed and published on HuggingFace.

## What's inside

- SKILL.md - instructions
- .catalog_stamp
- references/design-hook.md - reference
- references/esmc.md - reference

## Questions

### Is ESMFold2 (Biohub) safe to install?

AIR scanned this exact version of ESMFold2 (Biohub) and flagged nothing. AIR's verdict: safe. The verdict is named by the content that was read, at commit 05561a42bb76, so it cannot drift onto a version nobody scanned. The full report is at https://airmarket.ai/security/esmfold2.

### How do I install ESMFold2 (Biohub)?

Open https://airmarket.ai/app/esmfold2 on Air Market and use the install action: Air Market hands Claude a prompt naming this exact skill, and Claude sets it up. Source, pinned to the exact commit this listing describes: https://github.com/UnicomAI/wanwu/tree/05561a42bb76e01caacedd5febd534d8508869eb/configs/microservice/bff-service/configs/agent-skills/claude-science/esmfold2. Install from that link, not the branch.

## Related on Air Market

- [More Research listings](/category/research)
- [Everything by UnicomAI](/@unicomai)

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Canonical URL: <https://airmarket.ai/app/esmfold2>