---
title: "🧬 Variant Annotation - Air Market"
description: "A VCF file is a long list of variants with no indication which ones matter. This adds what is known about each one, including clinical significance and how often it shows up in the population, then r…"
canonical: "https://airmarket.ai/app/variant-annotation"
---

[Air Market](/) / [Data & Analytics](/category/data) / 🧬 Variant Annotation

Skill by [ClawBio](/@clawbio)

# 🧬 Variant Annotation

Turn a list of variants into a ranked shortlist worth reading

## What this does

A VCF file is a long list of variants with no indication which ones matter. This adds what is known about each one, including clinical significance and how often it shows up in the population, then ranks them. Reach for it when you have variant calls and need to know where to look first.

### Top 3 things it does for you

- Annotate the variants in a VCF
- See which variants are clinically significant
- Check how common a variant is in the population

## Information

**🧬 Variant Annotation at a glance**

|  |  |
| --- | --- |
| Kind | Skill |
| Publisher | [ClawBio](/@clawbio) |
| Category | [Data & Analytics](/category/data) |
| Works with | Agent Skills - an open standard supported by 40+ agents |
| Version | 0.1.0 |
| Size | 209 KB |
| Licence | MIT |
| Repository | [ClawBio/ClawBio](https://github.com/ClawBio/ClawBio/tree/5ae5a62b9c7ba223fc71c923718bbc320e181afa/skills/variant-annotation) |
| GitHub stars | 1,114 (as of Nov 2026) |

## Security report

**Verified.** AIR scanned this exact version of 🧬 Variant Annotation and flagged nothing. AIR's verdict: **safe**.

**What 🧬 Variant Annotation's check was run against**

|  |  |
| --- | --- |
| Commit | 5ae5a62b9c7ba223fc71c923718bbc320e181afa |
| Content hash | 5657e7e1b5011705b406b8c6abec6e0e72d029e4d0b1777f588b3d762b832260 |
| Files read | [Browse the files at this exact commit](https://github.com/ClawBio/ClawBio/blob/5ae5a62b9c7ba223fc71c923718bbc320e181afa/skills/variant-annotation/SKILL.md) |

A scan is named by the exact content it read, not by a version number. A different version is a different artifact, and nothing here applies to a version AIR has not scanned.

[Read the full security report for 🧬 Variant Annotation](/security/variant-annotation)

## About 🧬 Variant Annotation

Annotates the variants in a VCF using the Ensembl VEP REST service, adding ClinVar significance and population frequency context from gnomAD.

The annotated variants come back with a prioritized ranking, so the list arrives ordered rather than flat.

## What's inside

- SKILL.md - instructions
- example_data/synthetic_clinvar_panel.vcf
- figures/variant_annotation_summary.png
- requirements.txt - reference
- tests/test_variant_annotation.py - script
- variant_annotation.py - script

## Questions

### Is 🧬 Variant Annotation safe to install?

AIR scanned this exact version of 🧬 Variant Annotation and flagged nothing. AIR's verdict: safe. The verdict is named by the content that was read, at commit 5ae5a62b9c7b, so it cannot drift onto a version nobody scanned. The full report is at https://airmarket.ai/security/variant-annotation.

### How do I install 🧬 Variant Annotation?

Open https://airmarket.ai/app/variant-annotation on Air Market and use the install action: Air Market hands Claude a prompt naming this exact skill, and Claude sets it up. Source, pinned to the exact commit this listing describes: https://github.com/ClawBio/ClawBio/tree/5ae5a62b9c7ba223fc71c923718bbc320e181afa/skills/variant-annotation. Install from that link, not the branch.

## Related on Air Market

- [More Data & Analytics listings](/category/data)
- [Everything by ClawBio](/@clawbio)

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Canonical URL: <https://airmarket.ai/app/variant-annotation>